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Biomaterials and soft materials

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Design and scaling up of theranostic nanoplatforms for health: towards translational studies

The symposium will focus on the design of multifunctional hybrid nanomaterials designed for theranostics in the biomedical field but with a focus on the scaling-up of these nanomaterials for translational studies. The recent advances in breakthrough products for therapy and early diagnosis will provide a strong basis for the symposium as well as the strategies for scaling-up of products in GMP conditions and fowling guidances of the European agency of medicaments.

Scope:

Cancer is growing worldwide and its incidence continues to increase as well as mortality associated with a + 51% increase of deaths worldwide between 2002 and 2030. The move towards personalized/precision medicine and new targeted therapies requires the development of highly efficient theranostic tools able to diagnose and monitor the evolution of the disease, evaluate the structural and physiological changes in tissues and cells and to monitor the effects of treatments by imaging. In nanomedicine, the goal is to develop multimodal nanoparticles (NPs) to speed up targeted diagnosis, to increase its sensitivity, reliability and specificity for a better management of the disease (patient’s care) and to treat the disease in a specific perzonalized manner in feedback mode.

Multimodality imaging (MRI, PET, SPECT, XR, ….) with two or more imaging modalities allows integration of the strengths of individual modalities while overcoming their limitations. By incorporating anatomical and functional imaging in a common hybrid imaging platform, a synergism in the imaging capabilities can be achieved, thus making it possible to precisely visualize and delineate structural and functional information. Combining multiple sources of information in multimodal and/or hybrid medical imaging can thus increase the diagnostic and prognostic power of medical imaging significantly.  Development of rational combinations of imaging modalities and statistical image analysis pipelines is critical for improved detection of cancer and monitoring of therapeutic response. Combination of therapies (hyperthermia, chemotherapy, protontherapy, radiotherapy…) to target individual cancer-specific vulnerabilities is a way to increase the efficacy of anticancer treatment. Therefore, besides precision diagnosis, other challenges for personalized nanomedicine are to develop tools to be able to test quickly different treatments and to follow-up the effect(s) of the treatments by imaging.

For precision cancer nanomedicine to fill its promise, active targeting with affinity ligands to achieve favourable specificity and biodistribution profiles is critical for accurate detection/monitoring and therapeutic efficacy.

Such smart approaches, when translated to clinical uses, would have a great impact on the cancer management to improve patient survival and quality of life.

However for further translation in clinics of such nanoplatforms, a key step is the scaling-up of these nanoplatforms by taking into account environmental considerations and also GMP conditions. Therefore, key challenges today is the developement of scaled-up synthesis methods such a continous flow synthesis of water based synthesis and also the analysis/control of by-products at each synthesis steps.

Hot topics to be covered by the symposium:

  • Design, synthesis and characterization of nanoparticles: inorganic, polymers, liposomes, dendrimers.
  • Targeting strategies
  • Multimodal Imaging (e.g. MRI, MPI, SPECT, PET)
  • Multimodal therapy (e.g, hyperthermia, curie theraphy)
  • Drug delivery
  • Nanotoxicology
  • In vitro and in vivo validation of nanoplatforms combining multimodal imaging and therapies
  • Scaling-up strategies of the nanoplatforms synthesis
  • New synthesis processes taking into account GMP and environmental considerations

Confirmed invited speakers :

  • Erme Türeli, CSO of MyBiotech GmbH, Germany: GMP manufacturing of iron oxide nanoparticles
  • Gemma Davies, UK: Designer therapeutic and diagnostic tools: From cancer to chemical weapons
  • Clare Hoskins, UK: Second generation nano-assassins for pancreatic cancer therapy
  • Olivier Tillement, France: Development of a chelating polymer for a medical device designed for metal extraction: start-up Mexbrain
  • Tambet Teesalu, Estonie, visiting professor, USA: Homing peptides for precision targeting of drugs and nanoparticles
  • Andrea Klimchenko, France: Fluorescent polymeric nanoparticles for molecular diagnostics
  • Alexandre Detappe, France: Functionalized ultrasmall nanoparticles as multimodal imaging biomarkers
  • Robert Muller, UMONS, Belgium: State of the art on MRI progresses
  • Christophe Drouet, Toulouse, France: Bio-inspired apatite particles: a multifunctional platform in nanomedicine
  • Helena Gavilan Rubio, University of Madrid, Spain:  a gram production for the synthesis of ferrite nanocubes for magnetic hyperthermia
  • Sergio Moya, CIC biomaGUNE: Supramolecular Polyamine Gene Vectors: Biological fate and Cancer Therapy
  • John Conthe, University of Turin, Italy: In-flow synthesis of thermo-responsive synthesis of magnetic nanoparticles for scale-up purpose
  • Rainer Tietze, University of Erlangen, Germany: Biofunctionalized iron oxide nanoparticles for diagnostic purposes
  • Nazila Kamaly, Faculty of Natural Sciences, Department of Chemistry, Imperial College London, UK: Stimuli Responsive Covalent Nanogels—A Chemically Versatile Drug Delivery Platform
  • Maya Thanou, Institute of Pharmaceutical Science at King’s, London, UK: NIR-Emitting Polymer Dots for Tissue Imaging
  • Zeev Rosenzweig, Department of Chemistry and Biochemistry at the University of Maryland Baltimore County, USA: Image guided triggered release nanoparticles
  • Gilles Bruylants, UL Bruxelles, Belgium: to be confirmed

Session on "drug delivery" driven by SFNanomedicine french association with the three invited speakers:

  • Ernst Wagner, Ludwig-Maximilians-Universität(LMU) München, Germany : RNA Medicines: Chemical Evolution of Nanocarriers
  • Pascal Fender, Lyon, France: Design of a viral-inspired nanoparticle for translational studies in infectiology and cancer
  • Elisabeth Garanger, ENSCBP, France: Engineering (bio)functionality in thermo-responsive elastin-like polymers: towards (bio)functional self-assemblies

Publication:

Thematic issue of Nanoscale (impact factor: 8.3)

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Symposium organizers
Nguyen TK THANHUniversity College London

Gower Street, London WC1E 6BT, U.K.

+44 2074916509
ntk.thanh@ucl.ac.uk
Sophie LAURENTUniversity of Mons (UMONS)

General, Organic and Biomedical Chemistry, 20 Place du Parc, 7000 Mons, Belgium

+32 65 373525
sophie.laurent@umons.ac.be
Sylvie BEGIN-COLIN (Main organizer)Institut of Physic and Chemistry of Materials of Strasbourg (IPCMS)

BP 43, 67034 Strasbourg cedex, France

+33 3 88 10 71 92
sylvie.begin@ipcms.unistra.fr
Teresa PELLEGRINOIstituto Italiano di Tecnologia

Via Morego 30, 16143 Geneo, Italy

Teresa.pellegrino@iit.it